A brain growing out of stem cells can develop in laboratory just like a human brain and may help shed light on conditions like Alzheimer’s disease and schizophrenia.
Researchers from United States conducted extensive genetic analyzes of socalled “organelles” that were allowed to grow in experimental dishes for up to 20 months, and found that artificial brains appear to grow in stages according to an internal clock that corresponds to development of real infant’s brains.
The results indicate that organelles are able to develop beyond “fetus” stage, in contrast to what was previously assumed. Given this, brain organoids may be able to mature to extent that scientists can use m to investigate diseases that affect adults such as dementia. .
In ir study, team created brain organelles using socalled induced pluripotent stem cells, which are capable of producing many different types of cells, and stem cells mselves were derived from skin and blood cells that were reprogrammed to embryonic state.
And when exposed to right mix of chemicals in right setting, stem cells grow in brain cells and organize mselves to produce threedimensional structures that repeat with specific aspects similar to evolution of real human brains.
Researchers are interested in growing organoids from stem cells because y have potential to revolutionize ways to investigate development of complex organs such as brain and respond to disease. In fact, scientists are already using semiorganelles in human brain to study neurodevelopmental and neurological disorders including autism and epilepsy.
The results of this new study indicate that it is actually possible for organelles cells to grow so that researchers can also study diseases that appear during adulthood, such as dementia and schizophrenia, according to British newspaper The Daily Mail.