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Numorphan is a powerful opioid analgesic used to treat moderate to severe pain that lasts more than a few days. This medication may also be used for other purposes.


What is the drug Nomorphan?

Numorphan or Opana is the brand name for Oxymorphone and is a very strong opioid analgesic, used to treat severe pain. Pain relief begins about 5-10 minutes after the injection, and after oral administration, it starts about 30 minutes later, and lasts about 3-4 hours for the rapid-acting tablets and 12 hours for the extended-release tablets.

Generic name of the drug oxymorphone
Brand Names Numorphan
drug classification Narcotic analgesics
Pharmaceutical Forms Rapid-Release Tablets – Extended-Release Tablets – Injections – Suppositories
drug manufacturer Amneal Pharmaceuticals

Reasons for using Nomorphan

Oxymorphone belongs to a group of medicines called narcotic analgesics, as it acts on the central nervous system to relieve pain, and the indications for its use are:

  • Treatment of moderate to severe pain, including labor pain.
  • It is given before surgery or general anaesthesia.
  • It is used to relieve anxiety in patients with breathing problems.
  • When the drug is used for a long time, it may lead to mental or physical dependence.
  • Severe withdrawal side effects can be prevented by gradually reducing the dose.

Contraindications to the use of Numorphan

  • NUMORPHAN should not be given to patients with hypersensitivity to oxymorphone hydrochloride.
  • The use of NUMORPHAN should be avoided in patients during an acute asthma attack.
  • The drug should not be used in patients with respiratory problems or upper airway obstruction.
  • Do not use oxymorphone in the treatment of pulmonary edema secondary to chemical respiratory irritants.
  • Pregnant or breastfeeding women should use the drug with caution.

Important tips before taking Nomorphan

Tips before taking Nomorphan
Tips before taking Nomorphan

When deciding to use oxymorphone, you must weigh the potential risks and benefits, and consider the following:

  • Allergy
    Tell your doctor if you have ever had an allergic reaction to this medicine or an allergy to any other medicines. If you are allergic to foods, preservatives, or dyes, you should also read the label carefully.
  • aging
    Elderly patients are undoubtedly more likely to have liver, heart, or lung problems. Caution should be exercised and the dose adjusted for patients receiving oxymorphone injection.

pregnancy and breastfeeding

As with other opioid analgesics, it is not yet known whether NUMORPHAN causes fetal harm when administered to a pregnant woman, and oxymorphone should be used with caution in pregnancy or for women of childbearing age, as this requires balancing the benefits of the drug against the potential risks to the fetus. Maternal and child health.

Prolonged use of opioids during pregnancy leads to withdrawal symptoms in the newborn that include:

  • convulsions, irritability;
  • Fever, vomiting, diarrhoea.
  • Excessive crying, tremors.
  • sneezing, yawning;
  • Increased respiratory rate.

It is also not known whether Nomorphan is excreted in human milk, but since most opioid drugs pass through breast milk, caution should be exercised when this drug is used when breastfeeding.

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How to take Nomorphan

You should use the medicine exactly as your doctor recommends and follow his directions:

  • Take this medication by mouth with a glass of water, and follow your doctor’s directions.
  • Take this medicine on an empty stomach, at least 1 hour before or 2 hours after eating.
  • Swallow only one tablet at a time.
  • Do not take Numorphan with food.
  • Do not stop taking the medicine unless on the advice of your doctor.

Nomorphan dosages

Nomorphan Dosages
Nomorphan Dosages

Dosage varies due to the presence of many factors that affect drug response, as follows:

  • The usual adult dose of NUMORPHAN injection, injected under the skin (subcutaneous injection) or intramuscularly:
    • 1 mg to 1.5 mg IM as an initial dose, then repeated every 4 to 6 hours, depending on the patient’s condition.
    • In the case of intravenous injection: 0.5 mg is given initially and the dose may be increased with caution.
    • For analgesia during labour, 0.5 to 1 mg IM is recommended.
  • Usual Adult Dose of NUMORPHAN Suppositories:
    • One 5 mg suppository is given every 4 to 6 hours.
    • The doctor may carefully increase the dose until the pain is relieved.
  • Usual Adult Dose for Tablets:
    • In cases of acute pain
      A 10-20 mg tablet is given orally every 4-6 hours when needed, and the dose can be increased by 5 mg increments.
    • In cases of chronic pain
      The long-acting tablets are given in a dose of 5 mg every 12 hours orally as an initial dose. The dose can be increased gradually by 5-10 mg every 12 hours, every 3-7 days.

What do you do if you forget to take a dose?

If you miss a dose of the medicine, take it as soon as you remember, but if you remember the missed dose near the time of the next dose, it is better to skip the missed dose, and do not use other treatments to make up for the missed dose.

What do you do if you take an overdose?

In the event of an overdose, seek emergency help immediately and if any of the following symptoms occur while taking oxymorphone:

  • A change in consciousness.
  • Skin coolness and moisture.
  • pupil constriction;
  • Lack of awareness or response.
  • breathing difficulties.
  • muscle weakness;
  • Low blood pressure or pulse.
  • Unconsciousness.
  • Cyanosis of the skin and nails with pallor of the lips.
  • Extreme drowsiness or unusual sleepiness.
  • Irregular, rapid or slow breathing.

NUMORPHAN should be used with caution during labour, as it may affect the fetal sinus heart rate.


Actions to avoid while taking this medicine

There are actions that must be avoided and some precautions that must be taken while taking Numorphan as follows:

  • Avoid using this medicine together with a monoamine oxidase (MAO) inhibitor within 14 days of each other.
  • Do not use oxymorphone with central nervous system depressants such as:
    • Allergy or cold medicine or antihistamines.
    • Sedatives, hypnotics, or pain medications.
    • Anesthetics and seizure medications
    • Barbiturates as well as muscle relaxants.
  • Contact a doctor immediately if one of the following symptoms is observed:
    • Sleep Apnea.
    • skin rash or itching;
    • Difficulty swallowing or breathing
    • Swelling of the mouth, face, or hands while you are using this medicine.

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Nomorphan side effects

Nomorphan side effects
Nomorphan side effects

Oxymorphine may cause some unwanted effects, and if they occur you will need emergency medical attention. Consult your doctor immediately if any of the following side effects occur while you are taking this medicine.

  • Less common side effects:
    • Headache.
    • Sweating and rapid breathing.
    • chest tightness;
    • Thirst and dry mouth.
    • Swelling in the hands, ankles or feet.
    • unusual tiredness or weakness
    • Skin wrinkles.
    • blurred vision
    • confusion.
    • decreased urination;
    • breathing difficulties.
    • Rapid heartbeat, fast heartbeat, or palpitations.
    • Dizziness, weakness, or lightheadedness when getting up suddenly from a lying or sitting position.
  • Rare side effects:
    • Chest pain or discomfort.
    • Cold sweats and chills.
    • Confusion about place and time
    • Decreased consciousness with drowsiness.
    • Deep or rapid breathing with dizziness.
    • difficulty urinating
    • difficulty sleeping
    • Difficulty swallowing.
    • itching or rash;
    • Cough with hoarseness.
    • Pale lips and blue skin.
    • Irregular or slow breathing.
    • Numbness in the feet, hands, and around the mouth.
    • Joint pain, stiffness, or swelling.
    • Swelling of the eyelids and around the eyes
    • Swelling of the face, lips or tongue.
    • Feeling the presence of things that do not exist, and seeing or hearing those things.
    • severe constipation;
    • stomach pain.
    • dullness, abnormal drowsiness, feeling lethargic;
    • severe vomiting;
    • irritability and restlessness;
    • skin redness;

Drugs that interact with Nomorphan

Some drug interactions occur when more than one drug is used at the same time, and drugs that interfere with the use of Nomorphan include:

  • fentanyl;
  • alprazolam;
  • apomorphine;
  • Atarax (Hydroxyzine).
  • Ativan (lorazepam).
  • Avenza (morphine).
  • Butrans (buprenorphine).
  • Demerol (meperidine).
  • Dilaudid (hydromorphone).
  • Lortab (acetaminophen/hydrocodone).
  • Lyrica (pregabalin).
  • Norco (acetaminophen/hydrocodone).
  • OxyContin (Oxycodone).
  • Percocet (acetaminophen/oxycodone).
  • Valium (diazepam).
  • Vicodin (acetaminophen/hydrocodone).
  • Xanax (Alprazolam).
  • Sodium amital (amobarbital).

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Alternative medicines to Numorphan:

There are alternatives belonging to the class of opiates and are equivalent to the effect of this drug, such as:

  • Opana
  • Oxymorphone Global

Other medicines that do not share the active ingredient with Numorphan, such as:

  • TRAMAL
  • Durogesic
  • Mefename
  • Brufen
  • Nureflex Junior

price of nomorphan

The drug costs about $60.95.


Frequently Asked Questions About Numorphan

What are the harms of mixing Numorphan with some herbs?

The degree to which the drug is absorbed by the body and is processed by the herbs is affected, and Numorphan becomes less effective, so you should consult your doctor before mixing these herbs while you are taking the drug.

How to reduce the risk of Numorphan drug?

  • Do not stop the doses of the drug all at once, and the drug should be withdrawn from the blood gradually under the supervision of a doctor.
  • Don’t take double doses, as you risk getting used to or addicted.

Numorphan, an opioid used to relieve pain, is generally safe when taken for a short period and as prescribed by your doctor. However, be careful as you may run the risk of opioid dependence and addiction when misusing this drug.