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Entacapone, which belongs to the group of anti-Parkinson’s disease medicines, is used alone or in combination with other medicines, such as levodopa, to treat the signs and symptoms of Parkinson’s disease. It can improve symptoms, such as tremor, stiffness, poor muscle control, and muscle spasms.

Parkinson’s disease is a chronic and progressive disorder, so if appropriate treatment is not provided to a patient in the initial stage of the disease, their symptoms may worsen over time.


What is entacapone?

Entacapone is used with levodopa and carbidopa or levodopa and benserazide to treat symptoms of Parkinson’s disease or Parkinson’s-like symptoms, such as tremor, stiffness, and difficulty moving.

Many people who take levodopa for Parkinson’s disease have problems with the effects of levodopa that wear off between doses, and this leads to a return or worsening of Parkinson’s disease symptoms.

Entacapone prevents a certain natural substance (transporter O-methyl-catechol) that breaks down levodopa in the body. This allows the levodopa to last longer so that it does not wear off before the next dose.

Generic name of the drug Entacapone
Brand Names Comtan
drug classification catechol-O-methyltransferase inhibitors
Pharmaceutical Forms tablets
drug manufacturer Orion Pharma Company

Reasons for using entacapone

Reasons for using entacapone
Reasons for using entacapone

Entacapone is used as an adjunct to levodopa and carbidopa to treat patients with idiopathic Parkinson’s disease. Entacapone is used during the later stages when the patient does not respond well to levodopa and carbidopa.


Contraindications to the use of entacapone

Entacapone tablets are contraindicated in the following cases:

  • Malignant skin cancer.
  • psychotic disorder;
  • Orthostatic hypotension.
  • Liver problems.
  • Bile duct obstruction.
  • hallucinations;
  • dyskinesia
  • Diarrhea.

Important tips before taking entacapone

To check if entacapone is right for you, let your therapist know if you have:

  • Low blood pressure.
  • Liver disease.
  • History of mental illness or psychosis.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking entacapone, so talk to your doctor if this occurs.

People with Parkinson’s disease may be more likely to develop skin cancer (melanoma), so discuss with your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.

pregnancy and breastfeeding

Entacapone falls into category C. There are no well-controlled studies in pregnant women, so entacapone should be used during pregnancy only if clearly needed.

  • Breastfeeding:

It is not known if entacapone passes into breast milk, and in order to protect the health of the fetus, a decision should be made either to discontinue nursing or to use entacapone.


How to take entacapone

Follow all instructions listed below when you start taking entacapone tablets.

  • Entacapone must be taken with carbidopa and levodopa. Entacapone alone will not treat the symptoms of Parkinson’s disease (Parkinson’s disease).
  • Entacapone can be taken with or without food.

Taking the medicine with food may help prevent nausea, which is a common side effect of entacapone tablets.

  • Drink plenty of fluids while you are taking entacapone.
  • Entacapone may cause you to fall asleep during normal daily activities. You may fall asleep suddenly, even after feeling alert. If this occurs, tell your doctor.
  • Call your doctor if you have persistent vomiting or diarrhea, or if you are sweating more than usual.

You may easily become dehydrated while taking entacapone, which could lead to very low blood pressure or a dangerous electrolyte imbalance.

  • You should not stop using entacapone suddenly, and follow your doctor’s instructions about reducing your dose.
  • Entacapone packet should be stored at room temperature away from moisture and heat.

Entacapone Dosages

Entacapone Dosages
Entacapone Dosages

The recommended dose of entacapone for the treatment of Parkinson’s disease is 200 mg orally with each dose of levodopa and carbidopa, up to a maximum of 8 times daily (maximum daily dose of 1600 mg daily), when entacapone should always be given together; Because it does not have an anti-Parkinson’s disease effect on its own.

What do you do if you forget to take a dose?

If you miss a dose of entacapone, take the missed dose as soon as you remember, and if it is almost time for your next dose, skip the missed dose and use the next dose at the usual time.

Do not suddenly stop entacapone without talking to your healthcare provider, as stopping it suddenly may worsen Parkinson’s disease.

What do you do if you take an overdose?

If you take too many entacapone tablets, call your health care provider, or seek emergency medical attention at once.

Read also: Entecavir


Actions to avoid while taking this medicine

Please follow the following recommendations with caution when using entacapone; For fear of side effects:

  • Entacapone may impair your thinking reactions, so be careful if you are driving, or doing anything that requires you to be alert.
  • When using entacapone, avoid getting up quickly from a sitting or lying position, as you may feel dizzy, just get up slowly and steady yourself to prevent falling.
  • Avoid drinking alcohol, as it may increase some of the side effects of entacapone.

Read also: Mylotarg


Entacapone side effects

Entacapone side effects
Entacapone side effects

Entacapone can cause common side effects, so tell your doctor if any of these symptoms are severe or do not go away:

  • Dizziness.
  • Diarrhea.
  • upset stomach
  • Movements you cannot control.
  • stomach pain.
  • drowsiness;

If you experience any serious side effects while using entacapone tablets, contact your doctor immediately:

  • breathing difficulties.
  • hallucinations;
  • High temperature.
  • Mental confusion.
  • muscle stiffness;
  • Weakness with or without fever.

Read also: Lidocaine


Drugs that interact with Entacapone

Taking entacapone with other medicines that make you sleepy can worsen this effect, so ask your doctor before taking entacapone with a sleeping pill, pain medicine, muscle relaxer, or medicine for anxiety, depression, or epilepsy.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with entacapone, especially:

  • isocarboxazid;
  • linezolid;
  • Methylene blue injection.
  • phenelzine;
  • tranylcypromine.

Read also: Nyelia drug


Alternative medicines to entacapone

Examples of other medications that can be used alone or with other medications to treat Parkinson’s disease include:

  • Carbidopa and levodopa (Sinemet).
  • Selegiline hydrochloride (Zelapar).
  • Tolcapone (Tesmar).
  • safinamide (Zadago).
  • Rasagiline (Azilect).

Read also: Voyte eye drops


Entacapone price in local markets

The state Concentration and dosage form price
Saudi Arabia
Egypt 200 mg tablets 50 EGP approx
Jordan 200 mg concentration tablets About 20 Jordanian dollars
Kuwait

Frequently asked questions about entacapone

Can entacapone tablets be crushed?

No, entacapone cannot be crushed, broken, or chewed.

Why is carbidopa and levodopa given together?

Levodopa converts to dopamine in the brain, which helps control movement, while carbidopa prevents the breakdown of levodopa in the bloodstream; So more levodopa can enter the brain.


Entacapone is one of the medicines used to treat Parkinson’s disease, but it does not show effectiveness unless it is used with levodopa and carbidopa, so keep receiving their doses together. So that you get satisfactory results.