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Enhertu is a drug used to treat breast cancer that has spread, or cannot be removed by surgery. It can only be used when the cancer produces a protein, called HER2, in large quantities on the surface of cancer cells, which makes the cancer cells grow more quickly.
Inherto is used on its own in patients who have received two or more HER2-targeting treatments. It contains the active ingredient trastuzumab diroxtican.
What is the medicine Inherto?
The active ingredient in Inherto, trastuzumab deroxetican, consists of two active ingredients bound together:
Trastuzumab is a monoclonal antibody (a type of protein) that has been designed to bind to HER2, which is found in large amounts in some cancer cells. By binding to HER2, trastuzumab activates cells of the immune system, which then kill cancer cells. Trastuzumab also prevents HER2 from stimulating the growth of cancer cells.
Diroxtecan is a toxin that kills cells as they try to divide and grow, and becomes active once the component of trastuzumab binds to HER2 and enters the cancer cell. Deroxetican blocks an enzyme called topoisomerase 1, which is involved in transcribing a cell’s DNA and is needed to make new cells. By blocking the enzyme, cancer cells are prevented from reproducing and eventually die.
|Generic name of the drug||fam-trastuzumab deruxtecan|
|drug classification||HER2 . inhibitors|
|Pharmaceutical Forms||In the|
|drug manufacturer||Daiichi Sankyo Pharmaceutical Co., Ltd.|
Indications for use of the drug Inherto
Inherto is a prescription medicine used for adults to treat:
Inherto treats breast cancer that cannot be removed surgically, or that has spread to other parts of the body (metastatic), as well as treats patients who have had previous treatment for anti-HER2 breast cancer.
Treating stomach cancer that has spread to areas near the stomach (locally advanced) or has spread to other areas of the body (metastatic). Inherto also treats patients who previously received a trastuzumab-based regimen.
It is not known if Inherto injection is safe and effective in children.
Contraindications to the use of Inherto
Inherto is contraindicated in patients with the following:
- Low levels of neutrophils.
- High or low blood pressure.
- Cardiomyopathy and heart failure.
- Blockage of a blood vessel due to a blood clot.
- Interstitial lung inflammation.
- lung disease;
- Pregnancy, or breast-feeding.
Important tips before taking Inherto
Before you receive Inherto injection, tell your healthcare provider about all of your medical conditions, including the following:
- Lung or breathing problems.
- Signs or symptoms of an infection.
- Any heart problems.
- if you are pregnant, or planning to become pregnant; Because inherto may harm an unborn baby.
- You are breast-feeding your baby, or planning to breastfeed.
pregnancy and breastfeeding
Inherto may cause fetal harm when administered to a pregnant woman. Therefore, the use of Inherto should be avoided by women who are pregnant, or who do not become pregnant within 7 months after their last dose.
There are no data regarding the presence of Inherto in breast milk, or the effects on breastfeeding, or milk production, but women are advised not to breast-feed during treatment with Inherto and for 7 months after the last dose.
How to take inherto
Here are the points to follow when starting to receive inherto injections:
- In order to prevent medication errors, check the vial label; To make sure that the medicine being prepared is Inherto, and not trastuzumab or ado-trastuzumab emtancin.
- It is possible to dilute inherto before intravenous infusion.
- If the prepared Inherto solution is stored refrigerated (2°C to 8°C), allow the solution to reach room temperature before administration.
- Cover the infusion bag to protect it from light.
- Do not mix Inherto with other medicines, or give other medicines through the same intravenous line.
- Breast Cancer Dosage:
The recommended dose for breast cancer is 5.4 milligrams per kilogram of body weight, and you will receive the injection once every 3 weeks as an infusion.
- Dosage for stomach cancer or stomach and esophageal cancer:
The recommended dose for stomach cancer is 6.4 mg/kg, and you will receive this dose by intravenous infusion once every 3 weeks.
What do you do if you forget to take a dose?
If you miss a dose of Inherto, reschedule your appointment; to get your dose as quickly as possible; Then, adjust your schedule so that you continue to receive the doses every 3 weeks.
What do you do if you take an overdose?
If you take too much Inherto, call your health care professional or a hospital emergency department right away, even if you do not develop any symptoms.
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Actions to avoid while taking this medicine
You must adhere to all restrictions placed by your doctor on foods, drinks, and usual daily activities while receiving Inherto injection.
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Inherto side effects
Inherto can cause mild or serious side effects.
Minor side effects
Minor side effects of Inherto may include:
- Vomiting and nausea.
- Upper respiratory infection, such as the common cold.
- lack of appetite
- mouth ulcers;
- hair loss;
- Digestive problems, including indigestion, constipation, and diarrhea.
Serious side effects
Serious side effects of Inherto are not common, but can occur, and these may include:
- allergic reaction;
- Serious lung disease, including interstitial lung disease or pneumonia.
- Blood disorders, such as anemia and thrombocytopenia.
- decreased heart function;
- harm to the fetus.
Read also: Onevaid
Drugs that interact with Enhertu
Some drugs interact with Inherto, so it is important that you tell your doctor about any medications you are currently taking, or if you have started or stopped taking any while receiving cancer treatment. Also tell your doctor about any over-the-counter medications, vitamins, minerals, or herbal products you’re taking.
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Alternative medicines for Inherto
Examples of other medications that may be used to treat protein-positive breast cancer include:
- Trastuzumab (Herceptin).
- Ado trastuzumab emtancin (Kadsyla).
- Neratinib (Nerlinx).
- Pertuzumab (Perjeta).
- lapatinib (Tykerb).
- Chemotherapy drugs, including:
- Docetaxel (Taxotere).
- Capecitabine (Xeloda).
Read also: Elocon
The cost of Inherto IV Powder for Injection 100 mg is about $2,563 and its price in local markets is not clarified yet.
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Frequently asked questions about Inherto
Is inherto chemotherapy?
Yes, Inherto is a chemotherapy drug, and it is also a targeted anti-cancer drug.
Does insurance cover Inherto?
Patients must have health insurance that covers the cost of Inherto, but not the full cost.
Enhertu is considered one of the drugs with excellent effectiveness against the spread of breast or stomach cancer; But you need to pay attention to the contraindications listed above; So as not to be exposed to severe complications.