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Emend is an antiemetic. It is used in patients from 6 months of age. In order to prevent the symptoms of nausea and vomiting resulting from receiving chemotherapy, what are the appropriate doses according to the age of the patient, and what are its possible side effects?

What is Emend?

Aprepitant, the active ingredient in Emend, is a neurokinin-1 (NK1) receptor antagonist. Aprepitant prevents a chemical in the body (substance P) from attaching to the NK1 receptor. When Substance P binds to these receptors, it causes nausea and vomiting, but by binding to these receptors, it can prevent nausea and vomiting caused by chemotherapy.

Generic name of the drug Aprepitant
Brand Names Emind
drug classification Neurokinin 1 receptor antagonists
Pharmaceutical Forms Capsules, or powder for oral suspension
drug manufacturer Merck & Co

Indications for use of Emend

Indications for use of Emend
Indications for use of Emend

The Food and Drug Administration has approved Emend for use with other anti-nausea or antiemetics; To prevent nausea caused by chemotherapy.

Some chemotherapy drugs can cause severe nausea, which may happen immediately after chemotherapy, or after a few days. Some other anti-nausea medications help relieve nausea once it occurs. However, Emend helps prevent this nausea before it occurs.

Emend can also prevent nausea and vomiting in adults after surgery. Emend oral suspension is approved for use by persons 6 months of age and older, and the capsule form is suitable for persons 12 years of age or older.

Contraindications to the use of Emend

Do not take Emend product if:

  • You are allergic to aprepitant, or any of the ingredients in Emend.
  • If you are also using any of the medicines listed below:
    • pimozide;
    • terfenadine;
    • astemizole;
    • cisapride.

Important tips before taking Emend

To make sure Emend is safe for you, tell your doctor if you have liver disease beforehand, and if you’re pregnant or breastfeeding, you shouldn’t have this injection if you’re pregnant.

Emend can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while you are using Emend, use a barrier form of birth control: a condom, diaphragm, or cervical cap; To prevent pregnancy, keep using this form for 1 month after your last dose of Emend.

pregnancy and breastfeeding

  • Amend for pregnant women:

Emend falls into category B. There are no good human studies with Emend, and because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

  • Emend while breastfeeding:

It is not known if Emend passes into breast milk, so a decision should be made to stop breast-feeding or to stop using Emend; So as not to expose your child to risks.

How to take Emend

Follow these recommendations when you start receiving Emend injection:

  • Take Emend exactly as your doctor has prescribed it.
  • Emend is taken orally.
  • Emend is not for long-term use, and you will likely only need one to three doses.
  • The first dose is usually given 30 to 60 minutes before chemotherapy.
  • Emend can be taken orally with or without food, and swallow the capsule whole.
  • Give Emend syrup using only the dosing syringe provided.
  • If you also take warfarin, you may need more prothrombin time tests after using aprepitant.
  • Store Emend capsules at room temperature away from moisture and heat.

Emend doses

Emend doses
Emend doses

The usual dose of Emend for adults and children 12 years of age is 125 mg orally one hour before the start of chemotherapy and 80 mg daily for the next two days, given with other medicines that also prevent nausea and vomiting, such as dexamethasone and ondansetron.

In children 6 months to 12 years of age, Emend is given by mouth, and the dose is based on the patient’s weight. Emend oral suspension is given one hour before the start of chemotherapy, and once daily for the next two days.

What do you do if you forget to take a dose?

If you miss a dose of Emend, take it as soon as you remember as long as it is not time for your next dose.

What do you do if you take an overdose?

If you take too many Emend doses, call your healthcare provider to tell them, as taking too much can cause headache and drowsiness. However, there are no reported cases of severe effects from overdoses on Emend.

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Actions to avoid while taking this medicine

Follow all of your doctor’s instructions regarding any restrictions he or she may have on food, beverages, or daily activities when a patient is using Emend.

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Emend side effects

Emend side effects
Emend side effects

Side effects can occur when taking Emend.

Common side effects

Here are the top 6 common side effects of Emend:

  • Tired.
  • Diarrhea.
  • Low white blood cells.
  • lack of energy;
  • stomach pain.
  • Increased liver enzyme.

Serious side effects

In rare cases, Stevens-Johnson syndrome can occur after taking Emend. Stevens-Johnson syndrome is a serious skin reaction that includes symptoms such as a severe rash, burning or itching. If you begin to have these symptoms, stop taking Emend and contact your health care provider right away.

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Drugs that interact with Emend

Emend can reduce the effectiveness of hormonal birth control medications for up to 28 days after you take your last dose of Emend. If you’re taking birth control medications, use backup forms of birth control during this time.

Another interaction is with the drug Coumadin (warfarin). Emend can decrease how well Coumadin works, so your doctor may adjust your Coumadin dose. You also should not take Emend with an antipsychotic medicine called Orape (Pimozide); Because it can cause a potentially life-threatening heart problem.

Taking Emend with the following medicines may also require a dose change:

  • Medrol (methylprednisolone).
  • Nizoral (ketoconazole).
  • Biaxin (Clarithromycin).
  • Sporanox (Itraconazole).
  • Rifadin (Rifampin).
  • Tegretol (carbamazepine).
  • Dilantin (phenytoin).

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Alternative medicines to Amend

In addition to Emend, there are other medications that prevent nausea and vomiting, and they are as follows:

  • Zofran (ondansetron).
  • Reglan (metoclopramide)

Read also: ONGLYZA

Emend price in local markets

The state Concentration and dosage form price
Saudi Arabia
Egypt 1 capsule of 125 mg + 2 capsules of 80 mg 462 EGP
Jordan 1 capsule 125 mg + 2 capsules 80 mg 31.07 JOD

Frequently asked questions about Emend

Can you take aprepitant and ondansetron?

Addition of aprepitant to ondansetron with or without dexamethasone is effective for the prevention of chemotherapy-induced nausea and vomiting in pediatric patients treated with moderate or severe chemotherapy.

How long does Emend stay in the body?

The effect of Emend can last for up to 28 days after your last dose.

Emend is an effective drug for nausea and vomiting, as it is used in cancer patients, so do not take this drug alone or on the advice of someone, except after consulting your doctor.