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Elzonris is a medicine used to treat certain types of leukemia in adults and children from two years of age and older. It belongs to a group of medicines called antineoplastics, which destroy cancer cells, but what are the doses of this medicine and the possible side effects of receiving it?

What is Elzoneris?

Elzonris contributes to the treatment of ameloblastic natural killer cell lymphoma, a rare blood disease, or bone marrow cancer. BPDCN has a large number of CD123 protein, and by targeting this protein on the surface of this tumor, the elezonris can find and kill it.

Generic name of the drug Tagraxofusp
Brand Names Elzoneris
drug classification Antineoplastic agents.
Pharmaceutical Forms injection
drug manufacturer Stemline Therapeutics

Reasons for using Elzonris

Reasons for using Elzonris
Reasons for using Elzonris

Elzonris is used to treat blastic plasmacytoid dendritic cell neoplasm in adults and children 2 years of age and older.

Contraindications to the use of Zonris

Do not use Elzonris if you have an allergy to the active ingredient tragaxofosb, or to any of the ingredients in this medicine.

Important tips before taking Elzonris

Before taking Elzonris, tell your doctor about all of your medical conditions, and inform him or her especially of the following:

  • If you are allergic to Elzoneris, or any of its ingredients.
  • Pregnant, or planning to become pregnant.
  • You are breast-feeding your baby, or you are preparing to breastfeed.

pregnancy and breastfeeding

  • Elzoneris and pregnancy:

No animal studies have been conducted, and no well-controlled studies have been conducted in pregnant women. However, because of how traaxofosb works, this medicine may harm your unborn baby.

  • Elzonris injection for breastfeeding:

It is not known if traaxofosb passes into breast milk. However, breast-feeding is not recommended while taking this medicine and for a week after stopping it. You and your health care provider must decide whether you will receive Elzoneris, or whether you will breastfeed.

  • Elzoneris and Fertility:

If you are a female who could become pregnant, you must use an effective method of contraception during treatment with Elzoneris, and for at least 1 week after your last dose.

How to take Elzoneris

Take Elzoneris exactly as prescribed, following all instructions listed below.

  • Your doctor will do blood tests; To make sure there are no conditions that would prevent you from using Elzoneris safely.
  • Elzonris is injected into a vein through an IV infusion, and your healthcare provider will give you this injection.
  • You may receive Elzoneris in a hospital or clinic setting. To treat any serious side effects quickly.
  • You may be given other medicines with Elzonris; To help prevent a serious side effect, or allergic reaction.
  • Elzonris is given in a 21-day treatment cycle, and you may need to use these injections only for the first five days of each cycle.
  • You may need frequent medical tests to make sure Elzoneris is not causing harmful effects, as cancer treatments may be delayed or permanently stopped depending on the results.

Elzoneris Dosages

Elzoneris Dosages
Elzoneris Dosages

The recommended dose of Elzoneris is 12 mcg/kg once daily for 5 days every 21 days. Dosage and frequency may change depending on medical exam results and vital signs.

What do you do if you forget to take a dose?

Call your doctor for instructions if you miss an appointment for an Elzonris dose.

What do you do if you take an overdose?

Elzonris is administered by a healthcare provider in a medical setting, which makes an overdose unlikely. However, if you suspect you have received an overdose, seek emergency medical attention.

Actions to avoid while taking this medicine

Follow all of your doctor’s instructions regarding any restrictions he or she may have on food, drinks, or daily activity while using Elzoneris injections.

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Elzonris side effects

Elzonris side effects
Elzonris side effects

Common side effects of Elzonris include:

  • Nausea and tiredness.
  • Swelling in the lower extremity of the body.
  • overweight.

The most serious side effects have been reported with Elzonris, including:

  • Capillary leak syndrome, in which fluids and proteins leak from blood vessels into surrounding tissues, and symptoms include:
    • Accumulation of fluid in the upper or lower extremities of the body.
    • overweight.
    • Shortness of breath.
    • Reduction of Blood pressure.
  • hypersensitivity; Tell your doctor immediately of any signs or symptoms of hypersensitivity, including:
    • rash.
    • Itch.
    • zoom.
    • swelling of the face;
  • Liver damage, the symptoms of which are the following:
    • feeling tired
    • Anorexia.
    • jaundice;
    • Pain in the upper right part of the abdomen.

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Drugs that interact with Elzonris

The following drugs may interact with Elzonris injection, and serious drug interactions may occur:

  • acarbose;
  • Acetohexamide.
  • albiglutide;
  • alogliptin;

Read also: Fosfomycin

Alternative medicines for Elzoneris

No drug interactions have been identified by the manufacturer of Elzonris injection; However, tell your doctor about all the medicines you take.

Read also: Fosamax

Elzoneris price

Elzonris intravenous product (1,000 mcg/mL) costs approximately US$1 for a supply of 1 mL, but its price in the local market is not currently available.

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Frequently asked questions about Elzonris

What is glioblastoma natural killer cell lymphoma?

NK-cell lymphoma is an extremely rare tumor, usually in elderly males, that appears in the skin with recurrent involvement of the bone marrow, blood and lymph nodes.

What does Stemline Therapeutics do?

Stemline Therapeutics is a biopharmaceutical company that develops oncology compounds that target cancer stem cells.

Elzonris is an effective treatment for some types of cancer, but follow your doctor’s instructions about any restrictions on food, beverages or usual daily activities.