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Afinitor (Afinitor) is a medicine used to treat some types of cancer, and it contains the active ingredient everolimus, which is used as an immunosuppressant. The drug interferes with the growth of cancer cells and prevents their spread in the body.


What is Afinitor?

Afinitor contains the active ingredient everolimus, which is a cancer treatment medicine and is used to treat some types of cancer by interfering with the growth of cancer cells, thus slowing their spread in the body.

Generic name of the drug Everolimus
Brand Names Avinator, Avinator Dispress
drug classification Selective immunosuppressants, inhibitors of the mammalian target of rapamycin
Pharmaceutical Forms 2.5 mg, 5 mg, 7.5 mg and 10 mg tablets.
drug manufacturer Novartis

Reasons for using Afinitor

Use of Afinitor
Use of Afinitor

Among the most important indications for the use of the drug Afinitor:

  • Some cases of kidney cancer.
  • breast cancer.
  • brain tumor;
  • Advanced cases of some types of stomach, intestine, or pancreatic cancer.
  • Convulsions or noncancerous (benign) tumors in patients with tuberous sclerosis complex.

Read also: Actos


Contraindications to the use of Afinitor

The drug is contraindicated in the following cases:

  • Allergy to the active ingredient everolimus, sirolimus or temsirolimus.
  • Diabetics.
  • Having a severe infection.
  • Anemia.
  • High blood fats.
  • Thrombocytopenia.
  • Low white blood cell count.
  • Liver diseases.
  • Acute renal failure.
  • Pregnancy and lactation.
  • Hepatitis B virus.
  • Fluid retention in the body.
  • The presence of protein in the urine.

Important tips before taking Afinitor

Before taking this medicine, tell your doctor if you have any respiratory problems or diseases such as: angina or chronic obstructive pulmonary disease (COPD). Also tell him if you have: liver disease or a history of hepatitis B, an active or chronic infection, diabetes or high blood sugar, high cholesterol. Also if you have kidney disease, high blood pressure, or if you are taking any vaccinations.

Taking Afinitor may delay wound healing, so you should stop taking the medication one week before any surgery and for two weeks after surgery.

pregnancy and breastfeeding

Everolimus should not be used during pregnancy, as it can cause severe harm to the fetus and may cause birth defects. It is recommended that you use a contraceptive method during treatment with it, and for at least 8 weeks after the end of treatment. A contraceptive method should also be used if the husband is treated with this medicine and for 4 weeks after taking the last dose. Also, you should stop breast-feeding while using the medicine, and for at least two weeks after taking the last dose of it.

Read also: Zandros Medicine


How to take Afinitor

Afinitor tablets for oral administration. Follow the doctor’s instructions about taking the medicine, and read the instructions for use carefully. Take Afinitor at the same time each day. You can take it with or without food, but it must be taken the same way each time.


Afinitor Dosages

The dose of the drug is determined according to the condition to be treated, as follows:

  • Breast cancer treatment: One 10 mg tablet once daily.
  • Renal cell carcinoma: one 10 mg tablet once daily.
  • Brain tumors: one 10 mg tablet once daily.
  • Advanced stages of gastrointestinal cancers: one 10 mg tablet once daily.
  • Convulsions and tuberous sclerosis complex: 1 tablet 5 mg once daily.

What do you do if you forget to take a dose?

If you forget to take a dose of Afinitor, take it as soon as you remember, but do not take it if you remember it after 6 hours have passed. Do not take a double dose to make up for the missed dose.

What do you do if you take an overdose?

In the event of an overdose of the medicine, you must immediately refer to a doctor or to the emergency room.


Actions to avoid while taking this medicine

While taking Afinitor avoid the following:

  1. Have a live vaccine or have been in contact with someone who has recently had a live vaccine to avoid passing the virus to you (for example: measles, mumps, rubella, or rotavirus).
  2. Eat grapefruit, as it may interact with everolimus.
  3. Using a mouthwash that contains alcohol, iodine, peroxide, or thyme.

Read also: Acetylcysteine


Afinitor side effects

Afinitor side effects
Afinitor side effects

Common side effects of Afinitor include:

  • fever.
  • coughing;
  • infection.
  • diarrhea.
  • Weakness and fatigue.
  • mouth ulcers;
  • Nausea and loss of appetite.
  • Skin rash.
  • swelling;
  • Absence of menstrual cycles.
  • headache;
  • High blood sugar.

Afinitor can cause serious, and sometimes fatal, side effects. Refer to a doctor immediately if you notice any of the following symptoms, or minor symptoms persist for a long time:

  • Symptoms of an allergic reaction, such as: swelling of the face, lips, tongue or throat.
  • Mouth ulcers, gingivitis, or difficulty swallowing.
  • Symptoms of infection, such as: fever, chills, rash, joint pain, fatigue.
  • Respiratory problems, such as: cough, chest pain, difficulty breathing, wheezing.
  • Symptoms of kidney problems such as little or no urination, swelling of the body.
  • Symptoms of liver problems, such as: loss of appetite, dark urine, yellowing of the skin or eyes, pain in the upper part of the stomach.

Taking Afinitor may make hepatitis B patients get worse or get it again after they recover from it. The risk of infection or bleeding may also increase, so you should have regular check-ups while taking the medicine.


Drugs that interact with Aventor

Taking Afinitor may interact with some other medicines, causing allergic reactions, or the effect of one medicine on the effectiveness of the other, such as:

  • Heart or blood pressure medications belonging to the class of ACE inhibitors.
  • Antibiotics and antifungals.
  • Hepatitis C or AIDS medications.
  • Epilepsy medications.
  • St. John’s wort.
  • Tuberculosis medication.
  • Immunosuppressants, such as steroids, cancer medicines, and immunosuppressants to prevent rejection of transplanted organs.

Alternative medicines to Afinitor

Alternative medicines for Afinitor include:

  • certican tablets.
  • Zorters discs.

Read also: Ongentys drug


Storage conditions

Store Afinitor in its original package at room temperature, away from light, heat, and moisture. keep away from the reach of the children.


The price of the drug Aventor in the local markets

Afinitor 10 mg price
The price of the drug Afinitor
The state Concentration and dosage form price
Saudi Arabia
Egypt Afinitor Tablets 5 mg, 30 Tablets.

Afinitor Tablets 10 mg 30 Tablets.

9700 Egyptian pounds.

19100 Egyptian pounds.

Jordan
Kuwait

Frequently asked questions about Afinitor

How long can Afinitor be taken?

Afinitor is a long-term treatment, taken daily unless side effects appear. The average treatment period for Afinitor is about 24 weeks.

Aventor 10 does cause severe diarrhea?

Diarrhea is a common side effect of Afinitor, but it is not severe. If you experience severe or persistent diarrhea while using the drug, see your doctor.

What is everolimus and what are its uses?

It is a substance that treats cancer and is used as an immunosuppressant after organ transplants such as kidneys and livers (under another trade name).


Afinitor is a medicine used to treat some types of cancer, such as kidney, breast, brain tumors, and some advanced cases of digestive system cancers. It is also used to treat convulsions and benign tumors in patients with tuberous sclerosis complex.

The medicine contains the active ingredient everolimus, which is also used to suppress immunity after organ transplants. The price of Afinitor 10 mg in Egypt is 19100 pounds.